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Bibliometrics & citations, index terms.
Computer systems organization
Embedded and cyber-physical systems
Embedded systems
Embedded hardware
Publication trends and knowledge maps of global translational medicine research.
Translational medical research literatures have increased rapidly in last decades and there have been fewer attempts or efforts to map global research context of translational medical related research. The main purpose of this study is to evaluate the ...
Bibliometric data on psychology publications from 1977 through 2008 are modeled and forecasted for the 10 years following 2008. Data refer to the raw frequencies of the PsycINFO (94% English-language, mainly Anglo-American publications) and the English-...
To generate a research overview of digital banking, we did a bibliometric analysis. In our bibliometric analysis, we identified 2475 papers about digital banking that were published in the previous 10 years (2013–2023) from 1492 different sources ...
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The booming unconventional oil and gas industry, encompassing gas hydrates, deep coalbed methane, shale gas, tight oil, and more, confronts formidable geophysics and petrophysics hurdles. These resources, often trapped in low-permeability rocks, require innovative drilling, completion, and enhancement techniques, necessitating a deeper understanding of geophysics and petrophysics behaviors under complex geological conditions, wellbore stability and casing design, reservoir enhancement, and production increase measures, formation pressure management and fluid flow, problems involving coupled multifield geomechanics, imaging and interpretation of complex geological structures, and multi-source data fusion and comprehensive interpretation. Understanding and solving these issues is vital for sustainable and efficient production, ensuring energy security and economic viability. Explore the complex geophysics and petrophysics issues involved in unconventional oil and gas development in depth. This exploration aims to reveal how the microstructure of rocks and pore characteristics influence fluid flow and reservoir transformation. By optimizing drilling and fracturing parameters, as well as other engineering techniques, it is possible to improve the recovery rate of oil and gas. Simultaneously, it is crucial to ensure the safety and environmental friendliness of the extraction processes. Ultimately, these efforts provide a scientific foundation and technical support for the efficient and sustainable development of unconventional oil and gas resources." "This Research Topic aims to understand and solve geophysics and petrophysics issues involved in the unconventional oil and gas development process. We welcome contributions in the form of Original Research, Reviews, Research Reports, and Perspectives. Areas to be covered in this Research Topic may include, but are not limited to: • Geophysical behavior under complex geological conditions; • Application of AI in geological analysis; • Comprehensive evaluation and prediction of complex reservoirs; • Wellbore stability and casing design; • Reservoir enhancement and production increase measures; • Formation pressure management and fluid flow; • Multi-field coupling problems; • Imaging and interpretation of complex geological structures; • Multi-source data fusion and comprehensive interpretation; • Gas hydrates, deep coalbed methane, and shale gas.
Keywords : Geophysics, Petrophysics, Geo-energy, Geo-resources
Important Note : All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
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With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.
Press Release No. 100/2024 6 September 2024
EMBARGO: Monday, 9 September 2024, 11:00 (CEST)
A new molecular engineering technique can precisely influence the development of organoids. Microbeads made of specifically folded DNA are used to release growth factors or other signal molecules inside the tissue structures. This gives rise to considerably more complex organoids that imitate the respective tissues much better and have a more realistic cell mix than before. An interdisciplinary research team from the Cluster of Excellence “3D Matter Made to Order” with researchers based at the Centre for Organismal Studies and the Center for Molecular Biology of Heidelberg University, the university’s BioQuant Center as well as the Max Planck Institute for Medical Research in Heidelberg developed the technique.
Organoids are miniature, organ-like tissue structures derived from stem cells. They are used in basic research to gain new insights into human development or to study the development of diseases. “Until now it wasn’t possible to control the growth of such tissue structures from their interior,” states Dr Cassian Afting, a Physician Scientist at the Centre for Organismal Studies (COS). “Using the novel technique, we can now determine precisely when and where in the growing tissue key developmental signals are released,” emphasizes Tobias Walther, a biotechnologist and doctoral candidate at the Center for Molecular Biology of Heidelberg University (ZMBH) and the Max Planck Institute for Medical Research in Heidelberg.
The interdisciplinary research team of biologists, physicians, physicists, and materials scientists constructed microscopically small beads of DNA that can be “loaded” with proteins or other molecules. These microbeads are injected into the organoids and release their cargo when exposed to UV light. This allows the release of growth factors or other signal molecules at any given time and location within the developing tissue.
The researchers tested the process on retinal organoids of the Japanese rice fish medaka by precisely inserting microbeads loaded with a Wnt signal molecule into the tissue. For the first time, they were able to induce retinal pigment epithelial cells – the outer layer of the retina – to form adjacent to neural retinal tissue. Previously, adding Wnt to the culture media would induce pigment cells but suppress neural retina development. “Thanks to the localized release of signaling molecules, we were able to achieve a more realistic mix of cell types, thereby more closely mimicking the natural cell composition of the fish eye than with conventional cell cultures,” explains Prof. Dr Kerstin Göpfrich, a researcher in the field of synthetic biology at the ZMBH and the Max Planck Institute for Medical Research.
According to the scientists, the DNA microbeads can be flexibly adapted to transport many different signal molecules in various types of cultivated tissue. “This opens up new possibilities for engineering organoids with improved cellular complexity and organization,” states Prof. Dr Joachim Wittbrodt, who directed the research work together with Prof. Göpfrich. “More sophisticated organoid models could accelerate research on human development and disease and potentially lead to better organoid-based drug research,” states the Heidelberg developmental biologist, whose research group is located at the COS.
The new technique for creating more complex organoids was developed in the Cluster of Excellence “3D Matter Made to Order”, which is operated jointly by Heidelberg University and the Karlsruhe Institute of Technology. The research work was funded by the European Research Council (ERC) within the framework of an ERC Starting Grant for Kerstin Göpfrich, and the German Research Foundation. A paper with the research results was published in the journal “Nature Nanotechnology”.
C. Afting, T. Walther, O. M. Drozdowski, C. Schlagheck, U. S. Schwarz, J. Wittbrodt, K. Göpfrich: DNA microbeads for spatio-temporally controlled morphogen release within organoids. Nature Nanotechnology (9 September 2024).
Kerstin göpfrich research group, joachim wittbrodt research group, cluster of excellence 3dmm2o, pictorial material (available until 7 oktober 2024).
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Written ByZippia TeamUpdated June 25, 2024. 8 min read. Research and development engineers generally execute research and tests on product ideas, develop new products, and perform redesigns. They are employed in many industries, including manufacturing, electrical, and science-based companies. Their duties vary and depend on the industries they ...
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Ultimately, these efforts provide a scientific foundation and technical support for the efficient and sustainable development of unconventional oil and gas resources." "This Research Topic aims to understand and solve geophysics and petrophysics issues involved in the unconventional oil and gas development process.
A new molecular engineering technique can precisely influence the development of organoids. Microbeads made of specifically folded DNA are used to release growth factors or other signal molecules inside the tissue structures. ... "More sophisticated organoid models could accelerate research on human development and disease and potentially ...
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