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King's College London

Job id: 094988 . Salary: £43,205 - £46,732 per annum, including London Weighting Allowance .

Posted: 02 September 2024 . Closing date: 09 September 2024 .

Business unit: Faculty of Life Sciences & Medicine . Department: Department of Infectious Diseases .

Contact details: Michael Malim . [email protected]

Location: Guy's Campus . Category: Research .

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THIS VACANCY IS OPEN TO INTERNAL APPLICANTS ONLY

King’s College London is an internationally renowned university delivering exceptional education and world-leading research. The university is dedicated to driving positive and sustainable change in society and realising our vision of making the world a better place.  Through its commitment to exceptional education, impactful research and genuine service to society, King’s College London is creating positive change in its communities, both in London and on the world stage. The Strategic Vision 2029 looks forward to King’s College London’s 200th anniversary in 2029 and sets out ambitious plans in five key areas:

• Educating the next generation of change-makers
• Challenging ideas and driving change through research
• Giving back to society through meaningful service
• Working with our local communities in London
• Fostering global citizens with an international perspective

About the role

Animal cells express genes and pathways that naturally inhibit the replication of viruses.  The balance between these innate/intrinsic inhibitors and the many factors that promote replication establishes the tempo of virus infection and, ultimately, contributes to disease outcome.  Research in Prof Malim’s lab primarily addresses interactions between human cells, genes & proteins and pathogenic human viruses, including human immunodeficiency virus (HIV), influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – all with a view to understanding the fundamental principles that underpin virus infection, replication, transmission, zoonosis and pathogenesis.  Projects employ a multi-disciplinary blend of experimental approaches that draws upon molecular-genetic, cultured cell, biochemical, structural, bioinformatic and cohort-based methodologies.

The Malim lab, in collaboration with Luis Apolonia’s team, are applying fundamental knowledge of the HIV-1 life cycle and virus-host interactions to improve the efficiency and specificity of lentivirus-vector based genetic therapy methodologies. By identifying the host factors that promote or inhibit/restrict steps in infection between initial virus attachment to target cells and virus transcription, fresh approaches for optimising vector transduction will be suggested. This project will focus on applying unbiased, genome-wide CRISPR-activation screening to identify human genes whose upregulation enhances lentivirus-vector transduction. Once candidate genes and pathways have been identified in infection assays as well as through accompanying bio-informatic and statistical approaches, the mechanistic basis for activity will be interrogated using an established suite of molecular, cell biological and virological techniques. This knowledge can then be applied to the manipulation of the cellular environment to enhance vector transduction.

The role holder will join a team of post-doctoral fellows and research associates, post-graduate students and undergraduate/masters-level students to undertake discovery-inspired and internationally-distinctive research on the interplay between HIV-1 replication and the infected host cell from a genome-wide perspective.  The role requires skills in virology, molecular biology, cell biology, molecular genetics and bioinformatics/ statistics.  The appointee will be expected to display academic and technical leadership and innovation, culminating in research publications, presentations at international meetings/ conferences, and applications for extra-mural research funding.

This is a full-time post (35 hours per week), and you will be offered  a fixed term contract until 30 September 2026.

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

• PhD in relevant subject area*
• Experience in retrovirus- and lentivirus-vector infection studies
• Experience with molecular biology, cell biology methods and bioinformatics/ statistics
• Evidence of 4* research outputs or potential
• Track record of participating actively in the planning, execution and interpretation of research projects
• Ability to communicate effectively with clinical, academic and managerial colleagues; at King’s and externally
• Ability to self-motivate and work flexible hours
• Ability to work co-operatively and collegially as a team member

 *Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.

Desirable criteria

• Planning and preparation of applications for extra-mural research funding
• Peer-reviewed publications in high quality virology or more generalist journals, and/or evidence of oral/poster presentations at international scientific conferences
• Experience of working in a CL3 laboratory

Downloading a copy of our Job Description

Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “Apply Now”. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

Further Information

We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.

We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's.

We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.

To find out how our managers will review your application, please take a look at our ‘ How we Recruit ’ pages.

We are able to offer sponsorship for candidates who do not currently possess the right to work in the UK.

This post is subject to Occupational Health clearance.

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• Job Type Animal Technician Customer Service Manager Experienced Animal Technician Facility Manager ad NACWO Junior Animal Technician Licensed Animal Technician Mass Spectrometrist Named Veterinary Surgeon Principal Animal Technician/NACWO Scientific Officer Senior Animal Technician Surgery and Experimental Manager Trainee Animal Technician Veterinary Surgeon (NVS Traineeship)
• Location... Bracknell Cambridge Loughborough Portishead Rural area near Hull South Cambridge York

Careers in life sciences

If you don’t find your perfect job from our extensive list of positions, please get in touch with one of our life science recruitment specialists for further information. We have roles in specialisms such as laboratory animal, histology, immunology, microbiology, genetics, oncology, chemistry and more – so you’re sure to be able to make your next career move with the help of the Agenda Life Sciences team.

Animal Technician

• Customer Service Manager

Experienced Animal Technician

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Junior Animal Technician

Licensed animal technician.

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Named Veterinary Surgeon

Principal animal technician/nacwo, scientific officer.

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Surgery and Experimental Manager

Trainee animal technician, veterinary surgeon (nvs traineeship).

• Loughborough
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Found 19 Results Page 1 of 1

Salary: Up to £55,000 Location: Cambridge

Agenda has an exciting opportunity for a Veterinary Surgeon to work alongside the Named Veterinary Surgeons (NVS) to provide a comprehensive veterinary service to the animal species housed within university biomedical research facilities and ensure compliance with relevant government legislation. As an NVS trainee the role holder shall also receive training and support as part of a NVS traineeship in order to gain the experience and qualification necessary to attain Named Veterinary status.

Salary: Up to £57,696 Location: Cambridge

Agenda has an exciting opportunity for a Named Veterinary Surgeon to work in a prestigious institute. The Named Veterinary Surgeon (NVS) is a veterinary specialist legally required for institutions holding animals for research and development under the Animals (Scientific Procedures) Act (ASPA). Under the Veterinary Surgeons Act, the NVS has a professional duty to ensure the health and welfare of animals committed to their care.

Salary: Competitive Location: Cambridge

We have an exciting opportunity to join a large animal facility as surgery and experimental manager. The role will be embedded in the facility management team and working closely with them to deliver outstanding research support to a range of clients and academics.

Salary: Competitive Location: Loughborough

Agenda are recruiting for an experienced Scientific Officer to work within the Experimental Team of the Biological Resources unit. The aim of the post is to provide day to day care and welfare monitoring for the mice housed in the facility and to work alongside the research groups to support their work.

Agenda are recruiting for a Senior Scientist to join their client who are a leader in agricultural innovation and known for their breakthrough technology to work in the Analytical Methods and Metabolism team.

Salary: £25,285-£32,411 Location: Cambridge

Agenda are recruiting for an Experienced Animal Technician for one of our prestige clients based in Cambridge. We are looking for an individual who shows care and empathy towards animals under their charge and embraces the 3R’s ethos. You will be required to work to departmental Standard Operating Procedures standards and should have a keen eye for detail.

Unit/Facility Manager and NACWO

We have an exciting opportunity for a Unit Manager and NACWO to undertake the day-to-day management and operation of a large animal biomedical facility. The successful candidate will be the primary point of contact for Project and Personal Licence holders within the centre and will provide advice and guidance on Home Office regulations.

Salary: £25,138 to £27,181 Location: York

We are currently looking for a Trainee Animal Technician to join our clients team at a Biological Services Facility in York. In this role, you’ll support with animal welfare for researchers, as a trainee, you’ll have the opportunity to learn the ins and outs of animal care, from husbandry to health checks and facility upkeep – Don’t worry, you’ll receive plenty of support and on-the-job training to make sure you feel confident in your role and understand the importance of your work.

Salary: Up to £33,00 Location: Portishead

We have an exciting opportunity for a Principal Animal Technician/NACWO to ensure the smooth running of a large animal facility in a leading research establishment. You will play a vital part in supervising a team of technicians, managing the daily organisation of staff and research activities, as well as maintaining a high standard of animal care and ensuring that staff are well-trained in all necessary procedures.

Salary: £25,596-£27,405 Location: South Cambridge

On behalf of our client, we are looking to recruit an Animal Technician to provide daily animal husbandry, care and welfare within their Laboratory of Molecular Biology. The Ideal candidate will need to support the team, communicate well with researchers and be keen to develop their own skills. This role is for someone who cares for animals but is also research inclined.

Salary: Dependent on experience Location: Cambridge

Agenda have an exciting opportunity for a Licensed Animal Technician to join our growing team in Cambridge. You will join a team that combines impeccable scientific credentials with a passion for animal welfare and implementation of the 3R’s.

Salary: Up to £29,000 Location: Cambridge

We have an exciting new role for a passionate Licensed Animal Technician who is looking to progress their career. You will provide animal husbandry, care, and welfare within their department of biomedical services. The ideal candidate will need to support the team, communicate well with researchers and be keen to develop their own skills. This role is for someone who cares for animals but is also research-inclined.

Salary: Dependent on Experience Location: Cambridge

We have an exciting new role for a passionate Animal Technician who is looking to progress their career. You will be looking after laboratory animals and developing new skills to help with daily tasks such as husbandry, environmental enrichment, health checks and record keeping. This role will be working with a friendly and professional team within a scientific setting. You will have the opportunity to develop your skills and gain more qualifications through training opportunities.

Salary: £26,000-£33,000 Location: Cambridge

Agenda is the largest provider of Animal Technicians within the Life Science sector, so these positions are an exceptional opportunity for someone to develop in this field. We are looking for an adventurous individual who would like to contribute to the research industry while maintaining a high welfare standard.

Salary: £26,000-£32,270 Location: Cambridge

Temp – Perm Licensed Animal Technician

Salary: £25,994 - £30,585 Location: Cambridge

As a Licensed Animal Technician, you will be responsible for providing a high standard of service and being expected to follow key animal care protocols to ensure the welfare of all animals within the research facility.

This is a full-time role, working with our Cambridge based client, with the opportunity to transfer to their facility on a permanent basis on completion of a fixed term period.

Salary: £21,335 - £22,630 Location: Cambridge

Agenda has a fantastic opportunity for a Junior Animal Technician to work in our facility based in Cambridge. The successful candidate will be joining our facility management team to support the daily care, welfare, and environmental enrichment of laboratory animals. The successful applicant will have previous experience working with animals and will be expected to undergo further training and development in the role.

Agenda is looking to recruit an Animal Technician to join their team and help contribute to the facility’s technical excellence and successful operation. The successful candidate will be responsible for animal welfare and husbandry of the animals within their care and supporting the research staff.

Agenda Life Sciences, the largest provider of Animal Technicians within the Life Science sector, are working in collaboration with the University of Cambridge, best known for their pioneering work which has led to major improvements in people’s lives.